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Image Search Results
Journal: Scientific Reports
Article Title: Epigenetic and transcriptional dysregulation of VWA2 associated with a MYC -driven oncogenic program in colorectal cancer
doi: 10.1038/s41598-018-29378-7
Figure Lengend Snippet: Histone marks and DNA methylation in the VWA2 promoter region of normal (N, in yellow) and tumor (T, in orange) tissues from CRC patients 719, 726 and 727. Two different histone modifications, i.e. H3K4me3 and H3K27me3, were analyzed by FFPE ChIP-Seq. These three cases exhibited a significant increase in the active-chromatin mark H3K4me3 (left) and a significant decrease in the repressive-chromatin mark H3K27me3 (middle). Methylation values of Illumina HM450K array probes cg22923514 and cg10407585, located in the VWA2 CGI south shore, are shown (right). Case 719 did not exhibit clear changes in methylation. Cases 726 and 727 exhibited somatic hypomethylation at both probes.
Article Snippet: Chromatin was prepared from using
Techniques: DNA Methylation Assay, ChIP-sequencing, Methylation